Mechanisms and Biomarkers of Exercise-induced Bronchoconstriction: Current Insights and Future Directions. [Review]

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All Authors

Ameri, S.
Stang, J.
Walsted, E.
Price, OJ.

LTHT Author

Price, Oliver J

LTHT Department

Respiratory Medicine

Non Medic

Publication Date

2025

Item Type

Journal Article
Review

Language

Subject

Subject Headings

Abstract

Exercise-induced bronchoconstriction (EIB) refers to temporary lower airway narrowing that occurs during or after vigorous physical exertion, with a high incidence in athletes and individuals with pre-existing asthma. The pathophysiology of EIB is not completely understood, but it is thought to involve a complex interplay among airway epithelial changes, immune responses, and environmental interactions. Phenotypic differences are apparent among those affected by EIB. This clinical review aims to summarize the complex mechanisms underlying EIB, explore the role of biomarkers in the diagnosis and management, and identify current gaps in knowledge to pave the way for future scientific discoveries.

Journal

Immunology & Allergy Clinics of North America

URI

https://hdl.handle.net/20.500.14838/412

DOI

https://dx.doi.org/10.1016/j.iac.2024.08.009

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