Refractory fungal infection: Three case reports highlighting good practice.

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All Authors

Barnes, R.
Enoch, DA.
Ingram, W.
Martin, J.
Clay, J.
Tyler, N.
White, PL.

LTHT Author

Martin, Jessica
Clay, Jennifer

LTHT Department

Pathology
Oncology
Haematology

Non Medic

Publication Date

2024

Item Type

Journal Article

Language

Subject

Subject Headings

Abstract

Refractory invasive fungal disease is a significant clinical problem, with high morbidity, mortality and costs. The complex causes of refractory infection include breakthrough infection due to antifungal resistance (both innate and acquired), suboptimal therapy and impaired immune responses in critically ill or immunocompromised patients. This case series details three reports on the identification and management of refractory fungal infections, two cases of azole resistance and one case of resistant candidiasis, highlighting the importance of accurate diagnosis, monitoring, implementation of biomarkers (serological markers, PCR), antifungal susceptibility testing and antifungal stewardship to optimise management and minimise risks of emergence of drug resistance.

Journal

Medical Mycology Case Reports

URI

https://hdl.handle.net/20.500.14838/2683

DOI

https://dx.doi.org/10.1016/j.mmcr.2024.100688

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