Taking the direct route: menin inhibitors go straight to the frontline in KMT2A-rearranged acute leukemia.

Khan, AB.; Huntly, BJP.

Taking the direct route: menin inhibitors go straight to the frontline in KMT2A-rearranged acute leukemia.

All Authors

Khan, AB.

Huntly, BJP.

LTHT Author

Khan, Anjum

LTHT Department

Oncology
Haematology

Publication Date

2026

Item Type

Journal Article

Subject

HOSPITALISATION

Abstract

Menin inhibitors disrupt oncogenic transcription in KMT2A-rearranged leukemias, but responses are heterogeneous. A previous study highlighted the role of nongenetic resistance driven by altered chromatin context, including loss of KMT2C/D-UTX activity, underscoring the need for broader epigenetic profiling to guide therapy timing and combination strategy selection.