Subgroups of Steatotic Liver Disease Have Distinct Clinical Phenotypes.

Pekarska, K.; Burke, L.; Rowe, I.; Parker, R.

Subgroups of Steatotic Liver Disease Have Distinct Clinical Phenotypes.

All Authors

Pekarska, K.

Burke, L.

Rowe, I.

Parker, R.

LTHT Author

Burke, Laura
Rowe, Ian
Parker, Richard

LTHT Department

Abdominal Medicine & Surgery
Liver Unit
Hepatology

Publication Date

2025

Item Type

Journal Article

Abstract

Background and aims: Steatotic liver disease (SLD) describes a spectrum of liver disease caused by cardiometabolic risk factors (CMRF) and/or alcohol. We aimed to describe the effect of cumulative CMRF and alcohol in subgroups of SLD and compare clinical outcomes. Methods: Patients from a single centre with biopsy proven SLD were retrospectively included. Patients were classified according to consensus definitions into three subgroups of SLD. The risk of liver-related death or liver transplantation during follow-up was analysed considering competing risks. Outcomes were tabulated for ordinal groups of CMRF and alcohol intake. Results: 726 patients were included: 516 (71%) had metabolic dysfunction-associated steatotic liver disease (MASLD), 85 (12%) MASLD with increased alcohol intake (MetALD), and 125 (17%) had ALD. Patients were followed up for a median of 60.5 months (IQR 29-84.5), during which time 64 (8.8%) patients died, including 23 liver-related deaths. Competing risk regression analysis showed that ALD was associated with higher risk of liver-related death sHR 8.47 (95% CI, 2.26-31.8, P = 0.002) compared to MASLD. The risk of major adverse liver outcomes or liver-related death increased with the number of CMRF and with alcohol, showing a synergistic effect of these factors on patient outcomes. Conclusions: Amongst patients with SLD, patients with ALD have the greatest risk of adverse liver outcomes. Conversely, liver-related outcomes are less common in MASLD in the short to medium-term. This emphasises the need to identify and treat alcohol misuse as an important risk factor for adverse outcomes.