Making Sense of Differing Guidelines for Clostridioides difficile Infection. [Review]

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All Authors

Sehgal, K.
Feuerstadt, P.
Wilcox, MH.

LTHT Author

Wilcox, Mark

LTHT Department

Pathology
Microbiology

Non Medic

Publication Date

2025

Item Type

Journal Article
Review

Language

Subject

Subject Headings

Abstract

The Clostridioides difficile infection (CDI) epidemic has been impacting the world for years. Understanding accurate diagnostics is imperative to allow the appropriate patients to be treated and improve outcomes. This article leverages multiple global societal guidelines to focus on the evolving diagnostic tests available summarizing best diagnostic practices including 2-step diagnostic testing. Therapeutically, guideline recommendations more recently have favored fidaxomicin and incorporated immune-based therapies and microbial restoration therapies. As treatment options and guideline recommendations change, it is imperative to understand why these recommendations have evolved and understand current best diagnostic and therapeutic practices in managing CDI. Crown

Journal

Infectious Disease Clinics of North America

URI

https://hdl.handle.net/20.500.14838/1927

DOI

https://dx.doi.org/10.1016/j.idc.2025.07.010

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