Exploring the Association Between Psychogenic Non-epileptic Seizures and Mild Traumatic Brain Injury: A Systematic Review.
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All Authors
Mavroudis, I.
Padurariu, M.
Ciobica, A.
Romila, L.
Kamal, F.Z.
Petroaie, A.D.
Novac, B.
Iordache, A.
Ionescu, C.
Kazis, D.A.
LTHT Author
Mavroudis, Ioannis
LTHT Department
Neurosciences
Neurology
Neurology
Non Medic
Publication Date
2025
Item Type
Review
Language
Subject
Subject Headings
Abstract
Context: This systematic review explores the intersection between mild traumatic brain injury (mTBI) and psychogenic nonepileptic seizures (PNES). Evidence Acquisition: This review examines the prevalence, risk factors, and diagnostic challenges of PNES in the context of mTBI, while also exploring potential underlying mechanisms and clinical implications. Result(s): From the initial 1,354 studies, 7 were included in the final analysis. La France et al. reported a 44.6% prevalence of traumatic brain injury (TBI) in PNES, with 73% being mTBI (P < 0.001). Mokleby et al. found that 83% of PNES patients had minor head trauma, significantly associated with depression and post-traumatic stress disorder (PTSD) (P < 0.01). Salinsky et al. highlighted a strong link between mTBI, PTSD, and PNES in veterans (P = 0.002). The studies consistently reported high psychiatric comorbidity rates, including major depression and conversion disorder (P < 0.001). These findings emphasize the need for an integrated neurological and psychiatric approach to PNES in mTBI patients. Conclusion(s): The review concludes with an emphasis on the need for comprehensive care in managing PNES, especially considering the prominent role of psychiatric comorbidities. Future research directions include prospective studies, a focus on pediatric populations, and enhanced treatment strategies integrating neurological and psychiatric care.
Journal
Iranian Journal of Psychiatry and Behavioral Sciences