European Respiratory Society and European Society of Thoracic Surgeons clinical practice guideline on fitness for curative intent treatment of lung cancer.

Brunelli, A.; Hardavella, G.; Huber, RM.; Berghmans, T.; Frille, A.; Rodriguez, M.; Tietzova, I.; Depypere, L.; Asteggiano, R.; Batchelor, T.; Costantini, A.; De Ruysscher, D.; Durieux, V.; Faivre-Finn, C.; Ferguson, MK.; Langer, D.; Marczin, N.; Nagavci, B.; Novoa, N.; Pompili, C.; Rawlinson, J.; Snoeckx, A.; Tonia, T.; van Geffen, WH.; Williams, C.; Caruana, EJ.; Kabalak, PA.; Mansmann, U.; Fallet, V.; Kauffmann-Guerrero, D.; Paesmans, M.; Al Tawil, A.; Alhannoush, N.; Creamer, AW.; Kourouni, I.; Blum, TG.

European Respiratory Society and European Society of Thoracic Surgeons clinical practice guideline on fitness for curative intent treatment of lung cancer.

All Authors

Brunelli, A.

Hardavella, G.

Huber, RM.

Berghmans, T.

Frille, A.

Rodriguez, M.

Tietzova, I.

Depypere, L.

Asteggiano, R.

Batchelor, T.

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LTHT Author

Brunelli, Alessandro

LTHT Department

Thoracic Surgery

Publication Date

2025

Item Type

Journal Article
Practice Guideline

Abstract

A multidisciplinary panel of lung cancer experts with a special interest in functional evaluation of lung cancer patients, and lung cancer patient representatives, has been facilitated by the European Society of Thoracic Surgeons and the European Respiratory Society to provide healthcare professionals with practical and up-to-date recommendations for the assessment of patients' fitness for curative intent treatments for lung cancer. The panel formulated four PICO (population, intervention, comparison and outcomes) questions and seven complementary narrative questions. Both types of questions were assigned to groups of at least two experts. A medical librarian conducted the literature searches, and the authors selected relevant studies based on predefined inclusion criteria. Risk of bias was assessed using the QUIPS (Quality in Prognosis Studies) tool. Data were summarised and the certainty of evidence was assessed with GRADE (Grading of Recommendations, Assessment, Development and Evaluations) and the Evidence to Decisions framework was used to formulate recommendations. A series of multidisciplinary recommendations was formulated about the utilisation of pulmonary function tests, split lung function values, exercise tests, cardiologic testing, and the role of prehabilitation, sublobar resections, risk scores and comorbidities in selecting patients for curative intent treatment. This article has been co-published with permission in the European Respiratory Journal and the European Journal of Cardio-Thoracic Surgery.