Cellular therapies for bone repair: current insights. [Review]
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All Authors
Rodham, P.
Khaliq, F.
Giannoudis, V.
Giannoudis, PV.
LTHT Author
Rodham, Paul
Giannoudis, Peter V
Giannoudis, Peter V
LTHT Department
Orthopaedics
NIHR Leeds Biomedical Research Centre
NIHR Leeds Biomedical Research Centre
Non Medic
Publication Date
2024
Item Type
Journal Article
Review
Review
Language
Subject
Subject Headings
Abstract
Mesenchymal stem cells are core to bone homeostasis and repair. They both provide the progenitor cells from which bone cells are formed and regulate the local cytokine environment to create a pro-osteogenic environment. Dysregulation of these cells is often seen in orthopaedic pathology and can be manipulated by the physician treating the patient. This narrative review aims to describe the common applications of cell therapies to bone healing whilst also suggesting the future direction of these techniques.
Journal
Journal of Orthopaedics & Traumatology