Atrophic-pattern prostatic adenocarcinoma: a diagnostic pitfall.

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All Authors

Wong, K.W.E.
Singh, T.
Roulson, J.-A.

LTHT Author

Wong, Ka Wing Eric
Roulson, Jo-An

LTHT Department

Pathology
Histopathology

Non Medic

Publication Date

2025

Item Type

Article

Language

Subject

Subject Headings

Abstract

The atrophic pattern of prostatic adenocarcinoma is an uncommon histological pattern of acinar prostatic adenocarcinoma. Due to its deceptively benign histological appearance, it can be misdiagnosed as a benign entity. We report a case of atrophic pattern prostatic adenocarcinoma in an elderly male patient, highlighting key histopathological findings and prognostic implications. This pattern closely resembles benign atrophy, and we discuss the differences in architectural and cytological features, as well as the role of immunohistochemistry as a diagnostic adjunct. It is vital to recognise benign-appearing variants of prostatic adenocarcinoma to prevent misdiagnosis and ensure appropriate clinical management.

Journal

Diagnostic Histopathology

URI

https://hdl.handle.net/20.500.14838/2759

DOI

https://dx.doi.org/10.1016/j.mpdhp.2025.04.009

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