The local and systemic effects of immune function on fracture healing. [Review]
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All Authors
Evans, AR.
Giannoudis, PV.
Leucht, P.
McKinley, TO.
Gaski, GE.
Frey, KP.
Wenke, JC.
Lee, C.
LTHT Author
Giannoudis, Peter V
LTHT Department
Orthopaedics
Non Medic
Publication Date
2024
Item Type
Journal Article
Review
Review
Language
Subject
Subject Headings
Abstract
The immune system plays an integral role in the regulation of cellular processes responsible for fracture healing. Local and systemic influences on fracture healing correlate in many ways with fracture-related outcomes, including soft tissue healing quality and fracture union rates. Impaired soft tissue healing, restricted perfusion of a fracture site, and infection also in turn affect the immune response to fracture injury. Modern techniques used to investigate the relationship between immune system function and fracture healing include precision medicine, using vast quantities of data to interpret broad patterns of inflammatory response. Early data from the PRECISE trial have demonstrated distinct patterns of inflammatory response in polytrauma patients, which thereby directly and indirectly regulate the fracture healing response. The clearly demonstrated linkage between immune function and fracture healing suggests that modulation of immune function has significant potential as a therapeutic target that can be used to enhance fracture healing.
Journal
OTA International : The Open Access Journal of Orthopaedic Trauma