The effectiveness of autologous platelet concentrates in prevention and treatment of medication-related osteonecrosis of the jaws: A systematic review.
No Thumbnail Available
All Authors
Nowak, SM.
Sacco, R.
Mitchell, FL.
Patel, V.
Gurzawska-Comis, K.
LTHT Author
Nowak, Sylwia Maria
LTHT Department
Oral & Maxillofacial Surgery
Leeds Dental Institute
Leeds Dental Institute
Non Medic
Publication Date
2024
Item Type
Systematic Review
Journal Article
Meta-Analysis
Journal Article
Meta-Analysis
Language
Subject
Subject Headings
Abstract
The systematic review aims to answer the PICOS question: "Are the autologous platelet concentrates (APCs) an effective strategy in prevention and/or treatment of patients at risk of/affected by medication-related osteonecrosis of the jaws (MRONJ)?". A literature search was conducted via PubMed, MEDLINE, EMBASE, and CINAHL (January 2006 - September 2023). 30 articles were included, evaluating preventive (n = 8*) and treatment strategies (n = 23*). The risk of bias and quality of studies were assessed utilising ROB-2, ROBIN-1 and GRADE criteria. Meta-analysis was undertaken for eligible studies. The application of APCs demonstrated a statistically significant effectiveness in prevention of MRONJ in 86.13% (p < 0.001) but failed to achieve the same level of certainty in treatment of established MRONJ in 83.4% (p = 0.08). High levels of bias were identified; thus, the results should be interpreted with caution. More high quality prospective randomised controlled trials are needed to further evaluate the effectiveness of APCs in management of MRONJ.
Journal
Journal of Cranio-Maxillo-Facial Surgery