Paroxysmal nocturnal haemoglobinuria: Considerations for optimal pregnancy care. A case report.
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All Authors
Winton, C.
Dodd, E.
Ciantar, E.
Muus, P.
Griffin, M.
LTHT Author
Winton, Claire
Dodd, Eleanor
Ciantar, Etienne
Muus, Petra
Griffin, Morag
Dodd, Eleanor
Ciantar, Etienne
Muus, Petra
Griffin, Morag
LTHT Department
Women's Services
Obstetrics & Gynaecology
Obstetrics
Oncology
Haematology
Obstetrics & Gynaecology
Obstetrics
Oncology
Haematology
Non Medic
Publication Date
2026
Item Type
Journal Article
Language
Subject
ANTIBODIES, MONOCLONAL , HAEMOGLOBINURIA , HAEMOGLOBINURIA , PREGNANCY
Subject Headings
Abstract
Paroxysmal nocturnal haemoglobinuria (PNH) is a rare haematological disorder characterised by an acquired mutation in haematopoietic stem cells leading to intravascular haemolysis and thrombotic events. In untreated women, pregnancy amplifies the risks of these manifestations, leading to increased maternal and neonatal morbidity and mortality. In the UK, eculizumab is the only approved treatment for PNH in pregnancy. Eculizumab was found to be safe in pregnancy and reduces PNH-related complications. Multidisciplinary team care between haematologists specialising in PNH, obstetricians, anaesthetists and the midwifery team remains crucial. This report describes a case of a woman with known PNH successfully treated with eculizumab in her first pregnancy. She had a vaginal delivery and suffered no complications associated with PNH. The woman and her child are well one year post-delivery. We discuss the pre-conception, antenatal, intrapartum and postnatal management steps to provide optimal care to a woman with PNH in pregnancy.
Journal
Obstetric Medicine