The Role of Radiation Therapy in Unicentric Castleman Disease: A Case Report.

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All Authors

Rodriguez, C.
Rivera Rubi, L.
Menjivar, O.
Suazo, J.

LTHT Author

Suazo, Juan

LTHT Department

Oncology

Non Medic

Publication Date

2023

Item Type

Case Reports
Journal Article

Language

Subject

Subject Headings

Abstract

Castleman disease (CD) is a rare lymphoproliferative disorder characterized by localized (unicentric) or systemic (multicentric) lymphadenopathy. This study presents a unique case of a 29-year-old female with a rare pelvic presentation of unicentric Castleman disease, specifically the hyaline vascular variant. Despite surgical resection, an unresectable residual lesion prompted adjuvant radiotherapy and subsequent chemotherapy. The literature highlights surgical resection as the primary treatment for localized Castleman disease; however, radiotherapy and combined chemotherapy regimens like cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) have shown promise in unresectable cases, emphasizing a multidisciplinary approach. This case underscores the importance of tailoring treatment strategies for uncommon Castleman disease presentations.

Journal

Cureus

URI

https://hdl.handle.net/20.500.14838/1201

DOI

https://dx.doi.org/10.7759/cureus.49687

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