General practice chest X-ray rate is associated with earlier lung cancer diagnosis and reduced all-cause mortality: a retrospective observational study.

Bradley, SH.; Neal, RD.; Callister, ME.; Cornwell, B.; Hamilton, WT.; Abel, GA.; Shinkins, B.; Hubbard, RB.; Barclay, ME.

General practice chest X-ray rate is associated with earlier lung cancer diagnosis and reduced all-cause mortality: a retrospective observational study.

All Authors

Bradley, SH.

Neal, RD.

Callister, ME.

Cornwell, B.

Hamilton, WT.

Abel, GA.

Shinkins, B.

Hubbard, RB.

Barclay, ME.

LTHT Author

Callister, Matthew

LTHT Department

Respiratory Medicine

Publication Date

2025

Item Type

Journal Article
Observational Study

Abstract

BACKGROUND: Evidence is equivocal on whether general practice rates of investigation in symptomatic patients using chest X-ray (CXR) affect outcomes. AIM: To determine whether there is an association between rates of CXR requested in general practice and lung cancer outcomes. DESIGN AND SETTING: Observational study using data on English general practices. METHOD: Cancer registry data for patients diagnosed with lung cancer in 2014-2018 were linked to data on general practice CXRs from 2013 until 2017. Cancer stage at diagnosis (I/II versus III/IV) and 1-year and 5-year survival rates (conditional on survival to 1 year) post-diagnosis were reported by general practice quintile of CXR rate, with adjustment for population differences (age, smoking, prevalence of chronic obstructive pulmonary disease and heart failure, ethnicity, and deprivation) and by unadjusted category (low, medium, and high). RESULTS: In total, 192 631 patient records and CXR rates for 7409 practices were obtained. Practices in the highest quintile of CXR rate had fewer cancers diagnosed at stage III/IV compared with those in the lowest quintile (odds ratio [OR] 0.87, 95% confidence interval [CI] = 0.83 to 0.92, P<0.001). The association was weaker for the high unadjusted CXR category (OR 0.94, 95% CI = 0.91 to 0.97). For the highest adjusted quintile, hazard ratios (HRs) for death within 1 year and 5 years were 0.92 (95% CI = 0.90 to 0.95, P<0.001) and 0.95 (95% CI = 0.91 to 0.99, P = 0.023), respectively. For the high unadjusted CXR category, the HR for 1-year survival was 0.98 (95% CI = 0.96 to 0.99, P = 0.004), with no association demonstrated for 5-year survival. CONCLUSION: Patients registered at general practices with higher CXR use have a favourable stage distribution and slightly better survival. This supports the use of CXR in promoting earlier diagnosis of symptomatic lung cancer in general practice.