Treatment planning for lung cancer reirradiation accounting for previously delivered dose.

Walton, DP.; Thompson, C.; Lowe, D.; Pagett, CJH.; Lilley, J.; Svensson, S.; Eriksson, K.; Bokrantz, R.; Oden, J.; Murray, L.; Teo, M.; Appelt, A.

Treatment planning for lung cancer reirradiation accounting for previously delivered dose.

All Authors

Walton, DP.

Thompson, C.

Lowe, D.

Pagett, CJH.

Lilley, J.

Svensson, S.

Eriksson, K.

Bokrantz, R.

Oden, J.

Murray, L.

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LTHT Author

Thompson, Christopher
Lowe, Dominic
Pagett, Christopher
Lilley, John
Murray, Louise
Teo, Mark
Appelt, Ane

LTHT Department

Oncology
Medical Physics & Engineering
Radiotherapy Physics
Leeds Cancer Centre
Clinical Oncology

Non Medic

Clinical Scientist
Radiotherapy Physicist
Consultant Physicist
Physicist

Publication Date

2026

Item Type

Journal Article

Subject

RADIATION DOSAGE , DOSE-RESPONSE RELATIONSHIP, RADIATION , LUNG NEOPLASMS , WHOLE-BODY IRRADIATION , RADIOTHERAPY PLANNING, COMPUTER-ASSISTED

Abstract

Reirradiation is increasingly used for recurrent and new primary cancers, but dedicated planning tools are limited. We integrated deformable image registration and radiobiologically consistent dose accumulation into plan optimisation to improve plan quality and robustness, applying this approach to six lung cancer cases and comparing it with a manual, maximum point-dose method. The integrated automated approach delivered higher target doses within organ-at-risk limits, maintained robustness, and was qualitatively preferable in blinded comparison. It produced clinically acceptable dose distributions for 5/6 patients, versus 3/6 with the manual method, suggesting enhanced and potentially more efficient reirradiation planning.