State-of-the-art performance of deep learning methods for pre-operative radiologic staging of colorectal cancer lymph node metastasis: a scoping review.

Keel, B.; Quyn, A.; Jayne, D.; Relton, SD.

State-of-the-art performance of deep learning methods for pre-operative radiologic staging of colorectal cancer lymph node metastasis: a scoping review.

All Authors

Keel, B.

Quyn, A.

Jayne, D.

Relton, SD.

LTHT Author

Quyn, Aaron
Jayne, David

LTHT Department

Colorectal
General Surgery

Publication Date

2024

Item Type

Journal Article
Scoping Review

Abstract

OBJECTIVES: To assess the current state-of-the-art in deep learning methods applied to pre-operative radiologic staging of colorectal cancer lymph node metastasis. Specifically, by evaluating the data, methodology and validation of existing work, as well as the current use of explainable AI in this fast-moving domain. DESIGN: Scoping review. DATA SOURCES: Academic databases MEDLINE, Embase, Scopus, IEEE Xplore, Web of Science and Google Scholar were searched with a date range of 1 January 2018 to 1 February 2024. ELIGIBILITY CRITERIA: Includes any English language research articles or conference papers published since 2018 which have applied deep learning methods for feature extraction and classification of colorectal cancer lymph nodes on pre-operative radiologic imaging. DATA EXTRACTION AND SYNTHESIS: Key results and characteristics for each included study were extracted using a shared template. A narrative synthesis was then conducted to qualitatively integrate and interpret these findings. RESULTS: This scoping review covers 13 studies which met the inclusion criteria. The deep learning methods had an area under the curve score of 0.856 (0.796 to 0.916) for patient-level lymph node diagnosis and 0.904 (0.841 to 0.967) for individual lymph node assessment, given with a 95% confidence interval. Most studies have fundamental limitations including unrepresentative data, inadequate methodology, poor model validation and limited explainability techniques. CONCLUSIONS: Deep learning methods have demonstrated the potential for accurately diagnosing colorectal cancer lymph nodes using pre-operative radiologic imaging. However, several methodological and validation flaws such as selection bias and lack of external validation make it difficult to trust the results. This review has uncovered a research gap for robust, representative and explainable deep learning methods that are end-to-end from automatic lymph node detection to the diagnosis of lymph node metastasis.