Non-medicinal oral contrast in upper abdominal MRI for MR-guided radiotherapy: A scoping review.
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All Authors
Beasley, MR.
Henry, AM.
Bestall, J.
Cosgrove, VP.
Murray, LJ.
Burnett, C.
LTHT Author
Beasley, Matthew
Henry, Ann
Cosgrove, Vivian
Murray, Louise
Burnett, Carole
Henry, Ann
Cosgrove, Vivian
Murray, Louise
Burnett, Carole
LTHT Department
Oncology
Leeds Cancer Centre
Radiotherapy
Radiotherapy Research Projects
Medical Physics & Engineering
Radiotherapy Physics
Oncology
Leeds Cancer Centre
Radiotherapy
Radiotherapy Research Projects
Medical Physics & Engineering
Radiotherapy Physics
Oncology
Non Medic
Research Radiographer
Head of Radiotherapy Physics
Head of Radiotherapy Physics
Publication Date
2025
Item Type
Journal Article
Scoping Review
Scoping Review
Language
Subject
Subject Headings
Abstract
INTRODUCTION: Using non-medicinal oral contrast agents may aid safe delivery of magnetic resonance image-guided (MR-guided) radiotherapy by improving the ability to visualise and avoid excessive radiation dose to adjacent bowel/stomach. This scoping review aims to map the literature on non-medicinal oral contrasts used in upper-abdominal diagnostic or therapeutic magnetic resonance imaging (MRI) to find potential candidates for employing in MR-guided radiotherapy and identify gaps in knowledge for further study.
METHODS: A scoping review of non-medicinal oral contrast used in upper-abdominal MRI research followed a pre-defined protocol based on Arksey and O'Malley's framework. Data were charted and reported in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Scoping Reviews reporting guidelines.
RESULTS: Forty-seven studies from 1955 screened abstracts were charted. Thirty-one distinct non-medicinal oral contrast were identified, used primarily to enhance tissue visualisation (89 %) or observe motility (11 %) in diagnostic studies. All studies reported to be predominantly quantitative; only 13 % included participant experience via questionnaires and none used qualitative methods. No studies have examined the efficacy of non-medicinal oral contrasts in MR-guided radiotherapy planning or delivery.
CONCLUSION: Non-medicinal oral contrasts have been extensively investigated in diagnostic MRI to enhance gastrointestinal visualisation and assess motility. However, non-medicinal oral contrasts have not been investigated in the context of radiotherapy planning and treatment. Qualitative evaluation of the patient experience of non-medicinal oral contrasts in magnetic resonance image-guided radiotherapy should be considered alongside studies quantifying the potential clinical benefit.
IMPLICATIONS FOR PRACTICE: This review summarises the properties of non-medicinal oral contrasts and identifies critical gaps in the current evidence, particularly the absence of qualitative research in this domain and the unexplored potential for their application in MR-guided radiotherapy planning and delivery. Crown
Journal
Radiography (London)