Guideline for the management of Clostridioides difficile infection in pediatric patients with cancer and hematopoietic cell transplantation recipients: 2024 update. [Review]
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All Authors
Patel, P.
Robinson, PD.
Fisher, BT.
Phillips, R.
Morgan, JE.
Lehrnbecher, T.
Kuczynski, S.
Koenig, C.
Haeusler, GM.
Esbenshade, A.
LTHT Author
Phillips, Bob
Morgan, Jessica
Morgan, Jessica
LTHT Department
Children & Teenage Oncology & Haematology
Leeds Children's Hospital
Leeds Children's Hospital
Non Medic
Publication Date
2024
Item Type
Journal Article
Review
Review
Language
Subject
Subject Headings
Abstract
Our objective was to update a clinical practice guideline for the prevention and treatment of Clostridioides difficile infection (CDI) in pediatric patients with cancer and hematopoietic cell transplantation recipients. We reconvened an international multi-disciplinary panel. A systematic review of randomized controlled trials (RCTs) for the prevention or treatment of CDI in any population was updated and identified 31 new RCTs. Strong recommendations were made to use either oral metronidazole or oral vancomycin for non-severe CDI treatment, and to use either oral vancomycin or oral fidaxomicin for severe CDI. A strong recommendation that fecal microbiota transplantation should not be routinely used to treat CDI was also made. The panel made two new good practice statements to follow infection control practices including isolation in patients experiencing CDI, and to minimize systemic antibacterial administration where feasible, especially in patients who have experienced CDI.
Journal
EClinicalMedicine