Expanding the Genetic and Phenotypic Spectrum of POLRMT-Related Mitochondrial Disease.
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All Authors
Fassad, MR.
Valenzuela, S.
Olahova, M.
Collier, JJ.
Knowles, CVY.
Mavraki, E.
Elbracht, M.
Guzel, N.
Herberhold, T.
Kurth, I.
LTHT Author
McCullagh, Helen
LTHT Department
Leeds Children's Hospital
Children's Neurosciences
Children's Neurosciences
Non Medic
Publication Date
2026
Item Type
Journal Article
Language
Subject
Subject Headings
Abstract
Mitochondrial diseases are a complex group of conditions exhibiting significant phenotypic and genetic heterogeneity. Genomic testing is increasingly used as the first step in the diagnostic pathway for mitochondrial diseases. We used next-generation sequencing followed by bioinformatic data analysis to identify potentially damaging variants in the POLRMT gene (NM_005035.4) in six new affected individuals. Structural protein analysis predicted the detrimental impact of variants on POLRMT protein structure. Patients show extended phenotypic abnormalities often presenting early in life with features including global developmental delay, cognitive impairment, short stature and muscular hypotonia. This study expands the genetic and phenotypic landscape of mitochondrial disease associated with POLRMT variants.
Journal
Clinical Genetics