Cardiovascular disease risk in people of African ancestry with HIV in the United Kingdom.
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All Authors
Ko, S.
Dominguez-Dominguez, L.
Ottaway, Z.
Campbell, L.
Fox, J.
Burns, F.
Hamzah, L.
Ustianowski, A.
Clarke, A.
Kegg, S.
LTHT Author
Schoeman, Sarah
LTHT Department
Genitourinary Medicine
Non Medic
Publication Date
2024
Item Type
Journal Article
Language
Subject
Subject Headings
Abstract
OBJECTIVES: Our objective was to describe the prevalence of cardiovascular disease (CVD) risk factors in people of African ancestry with HIV in the UK.
METHODS: We conducted a cross-sectional analysis of CVD risk factors in Black people with HIV aged >=40 years and estimated the 10-year CVD risk using QRISK R3-2018. Correlations between body mass index (BMI) and CVD risk factors were described using Pearson correlation coefficients, and factors associated with 10-year CVD risk >=5% were described using logistic regression.
RESULTS: We included 833 Black people with HIV and a median age of 54 years; 54% were female, 50% were living with obesity (BMI >=30 kg/m2), 61% had hypertension, and 19% had diabetes mellitus. CVD risk >5% ranged from 2% in female participants aged 40-49 years to 99% in men aged >=60 years, and use of statins ranged from 7% in those with CVD risk <2.5% to 64% in those with CVD risk >=20%. BMI was correlated (R2 0.1-0.2) with triglycerides and diastolic blood pressure in women and with glycated haemoglobin, systolic and diastolic blood pressure, and total:high-density lipoprotein (HDL) cholesterol ratio in men. In both female and male participants, older age, blood pressure, diabetes mellitus, and kidney disease were strongly associated with CVD risk >=5%, whereas obesity, total:HDL cholesterol, triglycerides, and smoking status were variably associated with CVD risk >=5%.
CONCLUSIONS: We report a high burden of CVD risk factors, including obesity, hypertension, and diabetes mellitus, in people of African ancestry with HIV in the UK. BMI-focused interventions in these populations may improve CVD risk while also addressing other important health issues.
Journal
HIV Medicine