Genomic landscape of diffuse glioma revealed by whole genome sequencing.

Kinnersley, B.; Jung, J.; Cornish, AJ.; Chubb, D.; Laxton, R.; Frangou, A.; Gruber, AJ.; Sud, A.; Caravagna, G.; Sottoriva, A.; Wedge, DC.; Booth, T.; Al-Sarraj, S.; Lawrence, SED.; Albanese, E.; Anichini, G.; Baxter, D.; Boukas, A.; Chowdhury, YA.; D'Urso, P.; Corns, R.; Dapaah, A.; Edlmann, E.; Greenway, F.; Grundy, P.; Hill, CS.; Jenkinson, MD.; Trichinopoly Krishna, S.; Smith, S.; Manivannan, S.; Martin, AJ.; Matloob, S.; Mukherjee, S.; O'Neill, K.; Plaha, P.; Pollock, J.; Price, S.; Rominiyi, O.; Sachdev, B.; Saeed, F.; Sinha, S.; Thorne, L.; Ughratdar, I.; Whitfield, P.; Youshani, AS.; Bulbeck, H.; Arumugam, P.; Houlston, R.; Ashkan, K.

Genomic landscape of diffuse glioma revealed by whole genome sequencing.

All Authors

Kinnersley, B.

Jung, J.

Cornish, AJ.

Chubb, D.

Laxton, R.

Frangou, A.

Gruber, AJ.

Sud, A.

Caravagna, G.

Sottoriva, A.

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LTHT Author

Saeed, Fozia

LTHT Department

Neurosciences
Neurosurgery

Publication Date

2025

Item Type

Journal Article

Abstract

Diffuse gliomas are the commonest malignant primary brain tumour in adults. Herein, we present analysis of the genomic landscape of adult glioma, by whole genome sequencing of 403 tumours (256 glioblastoma, 89 astrocytoma, 58 oligodendroglioma; 338 primary, 65 recurrence). We identify an extended catalogue of recurrent coding and non-coding genetic mutations that represents a source for future studies and provides a high-resolution map of structural variants, copy number changes and global genome features including telomere length, mutational signatures and extrachromosomal DNA. Finally, we relate these to clinical outcome. As well as identifying drug targets for treatment of glioma our findings offer the prospect of improving treatment allocation with established targeted therapies.