Phenotypic characterization of people at risk of atrial fibrillation: protocol for the FIND-AF longitudinal cohort study.

Wahab, A.; Nadarajah, R.; Reynolds, C.; Bennett, S.; Ambakederemo, E.; Harris, M.; Younsi, T.; Joseph, T.; Raveendra, K.; Smith, A.; Bhatty, A.; Lip, GYH.; Swoboda, PP.; Wu, J.; Gale, CP.

Phenotypic characterization of people at risk of atrial fibrillation: protocol for the FIND-AF longitudinal cohort study.

All Authors

Wahab, A.

Nadarajah, R.

Reynolds, C.

Bennett, S.

Ambakederemo, E.

Harris, M.

Younsi, T.

Joseph, T.

Raveendra, K.

Smith, A.

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LTHT Author

Wahab, Ali
Nadarajah, Ramesh
Younsi, Tanina
Gale, Christopher

LTHT Department

Cardiology
Cardio-Respiratory

Publication Date

2024

Item Type

Journal Article
Multicenter Study

Abstract

AIMS: The Future Innovations in Novel Detection of Atrial Fibrillation (FIND-AF) longitudinal cohort study is a multi-centre prospective cohort study of patients identified at risk of atrial fibrillation (AF). The aim of the FIND-AF longitudinal cohort study is to provide multi-modal phenotypic characterization of these patients. METHODS AND RESULTS: A total of 1955 participants identified as at risk of AF by the FIND-AF algorithm from primary care electronic health record (EHR) data, aged 30 years and above and eligible for oral anticoagulation, will be recruited between October 2023 and November 2024 to receive home-based intermittent electrocardiogram monitoring. About 500 participants without diagnosed AF will then undergo cross-sectional phenotypic characterization including physical examination, symptoms assessment, serum blood biomarkers and echocardiography, and non-stress cardiac magnetic resonance imaging. Longitudinal information about cardio-renal-metabolic-pulmonary outcomes will be ascertained from linkages to EHR data. The study is funded by the British Heart Foundation (CC/22/250026). The study has ethical approval (North West-Greater Manchester South Research Ethics Committee reference 23/NW/0180). Findings will be announced at relevant conferences and published in peer-reviewed journals in line with the funder's open-access policy. CONCLUSION: The FIND-AF multi-centre prospective longitudinal cohort study aims to (i) provide evidence for the impact of comorbidities on AF genesis, (ii) uncover actionable targets to prevent AF, and (iii) act as a platform for cohort randomized clinical trials that investigate enhanced detection and prevention of AF.