MULTIPLE MYELOMA SYMPTOMS RELEVANT to PATIENTS and LINKED to DISEASE PROGRESSION: A SYSTEMATIC LITERATURE REVIEW and DELPHI PANEL.
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All Authors
Kortum, M.
Farrell, J.
Scheid, C.
Theurich, S.
Jackson, G.
Cook, G.
Alonso, R.
Lakhwani, S.
Shah, B.
Costa, L.
LTHT Author
Cook, Gordon
LTHT Department
Oncology
Leeds Cancer Centre
Haematology
Leeds Cancer Centre
Haematology
Non Medic
Publication Date
2024
Item Type
Conference Abstract
Language
Subject
BONE MARROW , DELPHI TECHNIQUE , DRUG THERAPY , FATIGUE , MULTIPLE MYELOMA , NAUSEA , VOMITING , PAIN , QUALITY OF LIFE , SURVEYS AND QUESTIONNAIRES , SAMPLE SIZE , SIGNS AND SYMPTOMS , SYSTEMATIC REVIEW AS TOPIC
Subject Headings
Abstract
Background: Multiple myeloma (MM) is defined by monoclonal proliferation of bone marrow plasma cells, causing significant morbidity due to its end-organ destruction. Aim(s): This study aimed to systematically identify symptoms of MM which are relevant to or impactful on patients and which can be linked to clinical progression Methods: A systematic literature review (SLR) and a Delphi Panel were conducted. The SLR was undertaken in Embase, Medline, Medline-In-Process, and PubMed and yielded 3,253 publications. After title and abstract screening, full-text screening was conducted for 450 publications. Delphi is a questionnaire technique that uses multiple iterations designed to develop a consensus of opinion. Three rounds of electronic questioning were undertaken with n=10 experts in MM. The study was conducted in a blinded manner, where the sponsor was not aware of each respondent's answers and the panellists were also blinded from their fellow panellists. All responses were anonymous. The threshold for consensus was set at >=70% agreement or a range of <=1 category Results: In total, the SLR identified 12 studies that discussed MM symptoms with potential links to disease progression and 20 studies in which the link with progression was not stated. In both types of studies, fatigue, pain and nausea/vomiting were the most reported symptoms. The Delphi consensus was that 'pain' and 'poor mobility' have a high or very high impact on a patient's quality of life and that 'drowsiness', 'fatigue', 'pain' and 'poor mobility' are linked to MM disease progression. Summary/Conclusion: This study has several strengths; a full SLR was undertaken, the panel consisted of experts in the field of MM, use of the Delphi methodology facilitated an in-depth exploration of attitudes and opinions that is not possible in quantitative surveys. Whilst there is no gold standard of sample size for Delphi panels further studies could confirm the results.
Journal
HemaSphere