CharActeristics, sizing anD outcomes of stenotic, tapered, rapHe-type bicuspid aOrtic valves treated with trans-catheter device implantation: Insights the AD HOC registry.

Buono, A.; De Biase, C.; Fabris, T.; Bellamoli, M.; Kim, WK.; Montarello, N.; Costa, G.; Zito, A.; Alfadhel, M.; Koren, O.; Fezzi, S.; Bellini, B.; Massussi, M.; Scotti, A.; Bai, L.; Mazzapicchi, A.; Giacomin, E.; Gorla, R.; Latini, A.; Fraccaro, C.; Sondergaard, L.; Strazzieri, O.; Boiago, M.; Busco, M.; Charitos, E.; Orbach, A.; Messina, A.; Bettari, L.; Navazio, E.; Paglianiti, DA.; Nagasaka, T.; Napodano, M.; Villa, E.; Angelillis, M.; Ielasi, A.; Landes, U.; Brambilla, N.; Bedogni, F.; Mangieri, A.; Saia, F.; Favero, L.; Chen, M.; Adamo, M.; Latib, A.; Petronio, AS.; Montorfano, M.; Makkar, RR.; Mylotte, D.; Blackman, DJ.; Barbanti, M.; De Backer, O.; Tchetche, D.; Maffeo, D.; Tarantini, G.

CharActeristics, sizing anD outcomes of stenotic, tapered, rapHe-type bicuspid aOrtic valves treated with trans-catheter device implantation: Insights the AD HOC registry.

All Authors

Buono, A.

De Biase, C.

Fabris, T.

Bellamoli, M.

Kim, WK.

Montarello, N.

Costa, G.

Zito, A.

Alfadhel, M.

Koren, O.

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LTHT Author

Alfadhel, Mesfer
Blackman, Daniel

LTHT Department

Cardiology
Cardio-Respiratory

Publication Date

2024

Item Type

Journal Article
Multicenter Study
Observational Study

Abstract

BACKGROUND: Raphe-type bicuspid aortic valve (BAV) is a potential hostile scenario in trans-catheter aortic valve replacement (TAVR) due to pronounced calcium burden, possibly associated with tapered valve configuration. Trans-Catheter heart valve (THV) sizing strategy (annular vs. supra-annular) is controversial in this valve subtype. OBJECTIVES: To describe the phenotypical characteristics of severe, tapered, raphe-type, BAV stenosis undergoing TAVR and to explore safety and efficacy of modern-generation THVs, analysing the impact of annular and supra-annular sizing strategies on short- and mid-terms outcomes. METHODS: This is a retrospective, multicenter registry enrolling consecutive stenotic Sievers type 1 BAV treated with TAVR. Study population was divided into tapered and non-tapered configuration according to MSCT analysis. Matched comparison between annular and supra-annular sizing groups was performed in tapered population. RESULTS: From January 2016 to June 2023, 897 patients were enrolled. Of them, 696 patients displayed a tapered configuration. Of those, 510 received a THV according to annular sizing. After propensity score matching 186 matched pairs were selected. Technical success (96.2 % vs 94.1 %, OR 1.61 [0.61-4.24], p = 0.34), 30-day device success (83.6 % in both groups, OR 1.42 [0.78-2.57], p = 0.25) and 30-day early safety (71.8 % vs 70.5 %, OR 1.07 [0.68-1.68], p = 0.78) were similar between the annular and supra-annular sizing groups; a higher post-TAVR gradient was observed in supra-annular group, although it was only 2 mmHg mean. At mid-term follow-up, the rate of clinical efficacy was 84.7 %. CONCLUSIONS: TAVR with modern-generation devices is safe and effective for tapered raphe-type BAV, showing comparable results for annular and supra-annular sizing strategies.