The Sjogren's Working Group: The 2023 OMERACT meeting and provisional domain generation.

Gordon, RA.; Nguyen, Y.; Foulquier, N.; Beydon, M.; Gheita, TA.; Hajji, R.; Sahbudin, I.; Hoi, A.; Ng, WF.; Mendonca, JA.; Wallace, DJ.; Shea, B.; Bruyn, GA.; Goodman, SM.; Fisher, BA.; Baldini, C.; Torralba, KD.; Bootsma, H.; Akpek, EK.; Karakus, S.; Baer, AN.; Chakravarty, SD.; Terslev, L.; D'Agostino, MA.; Mariette, X.; DiRenzo, D.; Rasmussen, A.; Papas, A.; Montoya, C.; Arends, S.; Yusof, MYM.; Pintilie, I.; Warner, BM.; Hammitt, KM.; Strand, V.; Bouillot, C.; Tugwell, P.; Inanc, N.; Andreu, JL.; Wahren-Herlenius, M.; Devauchelle-Pensec, V.; Shiboski, CH.; Benyoussef, A.; Masli, S.; Lee, AYS.; Cornec, D.; Bowman, S.; Rischmueller, M.; McCoy, SS.; Seror, R.

The Sjogren's Working Group: The 2023 OMERACT meeting and provisional domain generation.

All Authors

Gordon, RA.

Nguyen, Y.

Foulquier, N.

Beydon, M.

Gheita, TA.

Hajji, R.

Sahbudin, I.

Hoi, A.

Ng, WF.

Mendonca, JA.

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LTHT Author

Md Yusof, Md Yuzaiful

LTHT Department

NIHR Leeds Biomedical Research Centre

Publication Date

2024

Item Type

Journal Article

Abstract

Sjogren's disease (SjD) is a systemic autoimmune exocrinopathy with key features of dryness, pain, and fatigue. SjD can affect any organ system with a variety of presentations across individuals. This heterogeneity is one of the major barriers for developing effective disease modifying treatments. Defining core disease domains comprising both specific clinical features and incorporating the patient experience is a critical first step to define this complex disease. The OMERACT SjD Working Group held its first international collaborative hybrid meeting in 2023, applying the OMERACT 2.2 filter toward identification of core domains. We accomplished our first goal, a scoping literature review that was presented at the Special Interest Group held in May 2023. Building on the domains identified in the scoping review, we uniquely deployed multidisciplinary experts as part of our collaborative team to generate a provisional domain list that captures SjD heterogeneity.