Surgical Results after Neoadjuvant Nivolumab and Platinum-based Chemotherapy for Resectable Lung Cancer. A Multicentre European Real Clinical Practice Analysis.

Brunelli, A.; Mariolo, A.; Aigner, C.; De Antonio, DG.; Jimenez, M.; Hemead, H.; Hoffman, R.; Lodhia, J.; Nardini, M.; Mattioni, G.; Sinn, K.; Hoda, MA.; Novoa, N.; Davila, GR.; Gomez-Hernandez, MT.; Rivas-Duarte, C.; Bhatnagar, P.; Clarke, K.; Escriu, C.; Fakih, O.; Franks, K.; Bouaziz, K.; Calvo, V.; Sereno, M.; Provencio, M.; Girard, N.; Shackcloth, M.

Surgical Results after Neoadjuvant Nivolumab and Platinum-based Chemotherapy for Resectable Lung Cancer. A Multicentre European Real Clinical Practice Analysis.

All Authors

Brunelli, A.

Mariolo, A.

Aigner, C.

De Antonio, DG.

Jimenez, M.

Hemead, H.

Hoffman, R.

Lodhia, J.

Nardini, M.

Mattioni, G.

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LTHT Author

Brunelli, Alessandro
Lodhia, Joshil
Nardini, Marco
Clarke, Brendan
Franks, Kevin

LTHT Department

Thoracic Surgery
Oncology
Pathology
Transplant Immunology
Leeds Cancer Centre

Non Medic

Clinical Scientist

Publication Date

2025

Item Type

Journal Article
Multicenter Study

Abstract

OBJECTIVES: To evaluate the real clinical practice surgical outcomes following neoadjuvant nivolumab in combination with chemotherapy in a multicentre European cohort of patients. METHODS: Retrospective analysis on consecutive patients treated in 6 tertiary referral hospitals in Europe with neoadjuvant chemotherapy and immunotherapy (nivolumab) for stage II-IIIB non-small cell lung cancer (March 2023-December 2024). Surgical and pathological outcomes were assessed. RESULTS: A total of 340 patients started neoadjuvant treatment. Three hundred seventeen patients (93.2%) were able to proceed to surgery. Forty-seven percent of patients had surgery more than 6 weeks after completion of the last neoadjuvant cycle. Two hundred eight operations (66%) were started using a minimally invasive approach with a conversion rate of 18%. The most frequent resection was lobectomy in 86% of patients. Ninety-day postoperative mortality rate was 2.5%. The pathologic complete response occurred in 95 patients (30% of the surgical patients), major pathologic response in 167 patients (52.7% of the surgical patients). The incidence of pathologic complete response (P = .78) and major pathologic response (P = .26) were similar in patients with clinical stage II and III. Pathologic complete response rate was higher in patients with programmed death-ligand 1 (PD-L1) >= 50% compared to those with PD-L1 < 50% (37.5% vs 27.2%, P = .082). A higher pathologic complete response (39% vs 23%, P = .004) and major pathologic response (66% vs 45%, P = .001) were observed in squamous vs non-squamous histology tumours. CONCLUSIONS: The use of neoadjuvant nivolumab in association with platinum-based chemotherapy in the real clinical practice is safe and effective. Our real clinical practice data represent valuable information to be used during multidisciplinary treatment selection for clinical stage II and III resectable non-small cell lung cancer and shared decision-making.